Recovery
TB-500
TB-500 is a synthetic analogue of the naturally occurring peptide Thymosin Beta-4 (Tβ4), a ubiquitous 43-amino-acid protein that sequesters G-actin and regulates actin polymerization. Research in multiple animal models demonstrates its capacity to promote cell migration, accelerate wound healing, reduce inflammation, and stimulate angiogenesis. Its systemic distribution profile — enabled by its small molecular size — allows it to reach sites of injury efficiently, distinguishing it from locally acting growth factors.
Mechanism of Action
Binds G-actin monomers, modulating cytoskeletal dynamics; promotes keratinocyte and endothelial cell migration; downregulates inflammatory cytokines IL-1β and TNF-α; upregulates VEGF-mediated angiogenesis.
Research Applications
- → Cardiac tissue repair post-ischemia
- → Wound healing acceleration studies
- → Hair follicle regeneration models
- → Neuroregeneration and multiple sclerosis models
Analytical Validation
HPLC purity ≥ 98%; endotoxin < 1 EU/mg; molecular weight 4963.5 Da confirmed by MALDI-TOF; sterility by membrane filtration.
For research use only